“Its because the virus produces this protein - negative factor or Nef - which enters B cells to prevent antibodies being targeted to HIV. This process leaves other less-targeted immune responses intact - but since they pose little threat to the virus, HIV proliferates.”
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“But the common wisdom was that Nef never appeared in healthy immune cells.”
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“Its only a theory, but we believe the protein escapes from dying, infected cells nearby and then enters the bystander B cell.”
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