“Don't wait until everything is just right. It will never be perfect. There will always be challenges, obstacles and less than perfect conditions. So what. Get started now. With each step you take, you will grow stronger and stronger, more and more skilled, more and more self-confident and more and more successful.”

“In her own simple way, Rosa Parks changed the history of our nation. She forced us to recognize the dignity of every person. She was a prophet -- a common instrument of God inviting us and challenging us to a new vision of solidarity, equality and justice. We were blessed to have her as citizen of Detroit.”

“We recognize that many diseases we aim to treat have a strong genetic component. Additionally, we know some patients taking medicines show efficacy or experience side-effects, while others do not. Our understanding of all this has improved greatly but these areas remain as significant challenges in drug development.”

“As a majority member in the senate I can do a lot more for our district back here. We've seen the difference between Senator Meier and what he can do for the district and what I'm able to do just because of the make-up of both houses and it's an exciting opportunity and a challenge to know that.”

“Del is a lot different from anyone I have ever played, so I was excited about that. She's smart, but at the same time somewhat socially challenged. You might say communication is not her best skill, but I think by the end of the movie she learns something. She was a lot of fun to play.”

“It was definitely more challenging coming off the season that we had. Several schools had the same dates available that we did but did not want to play us. I think our home winning streak and the environment that our fans have created to make this such a special place to play all were factors.”

“It's definitely been a challenging first 10 days under coach Karl, ... He's really tough on me, and I like that because I know it's going to make me better and make me cut down some of my bad decisions on the court and make me that much smarter of a player.”

“Self-acceptance comes from meeting life's challenges vigorously. Don't numb yourself to your trials and difficulties, nor build mental walls to exclude pain from your life. You will find peace not by trying to escape your problems, but by confronting them courageously. You will find peace not in denial, but in victory.”

“The challenge is making sure that we know what each of the lenders is doing in the marketplace. Because the market is so extremely competitive, our producers need to know what 100 different lenders are doing versus five. Our success is dependent on our producers being very in tune with what's going on in the capital markets.”

“The reforms on the table really get to the meat of the matter, which is changing an institution envisioned for the post-World War II period to work in a very changed world. The challenge now is that after so much attention to expanding the Security Council, this package sounds like leftovers - when it's really the meat and potatoes of reform.”