The human race is a letdown, Ernest — a bad, bad letdown. And I’m disgusted with it. It thinks it’s progressed, but it hasn’t. It thinks it’s risen above the primeval slime, but it hasn’t. It’s wallowing in it. It’s still clinging to us, clinging to our hair and to our eyes and to our souls. We’ve invented a few things that make noises, but we haven’t invented one big thing that creates quiet. Endless, peaceful quiet. Something to pull over us like a gigantic eiderdown, something to deaden the sound of our emotional yellings and screechings and suffocate our psychological confusions.
For me, there isn't some miracle cure, this is my life, or my disease will progress and my life will change focus again, and I'll have another new life.I need C to stay right where he is now because for now, I don't know enough to move from where I am.My hypothesis is that the light will come back, both outside and inside me.I'm afraid and angry, but the light is a theory I want to prove.Until then, I just have to keep the experiment going with as many controls as possible.One bus, back and forth.One store.One man, his words under glass.
As is now generally admitted, a Soviet bomb would not have been achieved for several years more but for the success of Soviet espionage in obtaining secret information from Western scientists associated with the Manhattan Project. That is to say, political ideas in the minds of certain capable physicists and others took the form of believing that to provide Stalin with the bomb was acontribution to world progress. They were wrong. And their decisions show, once again, that minds of high quality in other respects are not immune to political or ideological delirium....In the Soviet case, those involved thought they knew better than mere politicians like Churchill. They didn't.
“They all want to be happy. They all think they should be happy. And they’re quick to trot out their most cherished document and point to where they were promised “life, liberty and the pursuit of happiness.” But you’ll find that though they all parrot that little phrase, they think none too hard about that word “pursuit”. To follow, to chase, to inquire, to hunt, to seek. To track in order to overtake and capture. This they don’t do. Instead, having been offered a promise of happiness, they progress to a feeling of entitlement for happiness, then make the leap that happiness should, therefore, be easily won, automatic. There’s too much wrong in there to even scratch at that!”
“This progression is a manifestation of synaptic pruning. When our brains are growing, we make more neurons than we need. As we navigate our lives, solving problems and adapting to different environments, we use certain networks of neurons more than others. These commonly used networks become more numerous and better able to compute information; then they streamline their connections and become more efficient. By the time we are adults, our brain networks are stripped down and specialized. We lose plasticity, but our cognition becomes better at solving the problems we are most likely to face.”
Somatic hypermutation gives rise to B cells bearing mutant immunoglobulin molecules on their surface. Some of these mutant immunoglobulins have substitutions in the antigen-binding site that increase its affinity for the antigen. B cells bearing these mutant high-affinity immunoglobulin receptors compete most effectively for binding to antigen and are preferentially selected to mature into antibody-secreting plasma cells. The mutant antibodies that emerge from the selection do not have a random distribution of amino-acid substitutions. The changes are concentrated at positions in the heavy-chain and light-chain CDR loops that form the antigen-binding site and directly contact antigen. As the adaptive immune response to infection proceeds, antibodies of progressively higher affinity for the infecting pathogen are produced – a phenomenon called affinity maturation. Affinity maturation is a process of evolution in which variant immunoglobulins generated in a random manner are subjected to selection for improved binding to a pathogen. It achieves in a few days what would require thousands, if not millions, of years of classical Darwinian evolution in a conventional gene. This capacity for extraordinarily rapid evolution in pathogen-binding immunoglobulins is a major factor in allowing the human immune system to keep up with the generally faster-evolving pathogens.
Objects and ObjectivesTo contemplate LEGO. Many colours. Many shapes. Many inventive and useful shapes. Plastic. A versatile and practical substance. Symbolic of the resourcefulness of man. Oil taken from the depths of the very earth. Distillation of said raw material. Chemical processes. Pollution. Creating a product providing hours of constructive play. For children all over the world. Teaching our young. Through enjoyment. Preparing them for further resourcefulness. The progress of our kind.A book. Many books. Proud liners of walls. Fingered. Taken out with great care. Held open. Gazed upon / into with something like awe. A medium for the recording of and communication of knowledge. From the many to the many. Down the ages. And of art. And of love. But do you hear the trees outside whispering? Do their voices haunt you? No wonder. They are calling for their brothers. Pulped. Pressed. Coated. Printed. Bound. And for their other brothers which made the shelves to hold them. And for the roof over them as well.From the very beginning - everything at cost. A cave man, to get food, had to deal with the killing. And the bones from one death proved very useful for implementing the death of another.
“The capacity expansion project for P&H Mining which was approved by our board in May will not be completed until the end of fiscal 2006. The only other new capacity that will be coming on line in the next 12 months is the shuttle car and motor centers of excellence for Joy Mining in Lebanon, Kentucky, though, for the most part, Joy Mining is constrained by supply chain limits rather than internal capacity. Therefore, it is imperative that our critical suppliers support us as we strive for increased revenues. Assuming that progress can be made in this area, we now believe that total revenues in the coming 12 months will be in the range of $2.15 to $2.35 billion.”
“I believe the single most significant decision I can make on a day-to-day basis is my choice of attitude. It is more important than my past, my education, my bankroll, my successes or failures, fame or pain, what other people think of me or say about me, my circumstances, or my position. Attitude keeps me going or cripples my progress. It alone fuels my fire or assaults my hope. When my attitudes are right, there is no barrier too high, no valley too deep, no dream too extreme, no challenge too great for me.”
He had a book to finish. Ten-thousand words. The other ninety thousand had been difficult. This last tenth seemed impossible. His plot had become derailed. He was unable to see his way through the smoke and coke dust of a mythical railway track that should stretch ahead. Yes, the characters were there, good and solid. Indeed, the story's engine was strong and had shunted yet forward and forward, with only one or two sharp halts. But six weeks ago he met the bumpers. R. was now stuck in a deserted station, his progress blocked. ("Out Back")