The rediscovery of Mendel's laws of heredity in the opening weeks of the 20th century sparked a scientific quest to understand the nature and content of genetic information that has propelled biology for the last hundred years. The scientific progress made [since that time] falls naturally into four main phases, corresponding roughly to the four quarters of the century.""The first established the cellular basis of heredity: the chromosomes. The second defined the molecular basis of heredity: the DNA double helix. The third unlocked the informational basis of heredity [i.e. the genetic code], with the discovery of the biological mechanism by which cells read the information contained in genes, and with the invention of the recombinant DNA technologies of cloning and sequencing by which scientists can do the same." The sequence of the human genome, the project asserted, marked the starting point of the "fourth phase" of genetics. This was the era of "genomics" - the assessment of the entire genomes of organisms, including humans. There is an old conundrum in philosophy that asks if an intelligent machine can ever decipher its own instruction manual. For humans, the manual was now complete. Deciphering it, reading it, and understanding it would be quite another matter.

I'm struck by the difficulty I had in formulating it. When I think back now, I ask myself what else it was that I was talking about in Madness and Civilization or The Birth of the Clinic, but power? Yet I'm perfectly aware that I scarcely ever used the word and never had such a field of analyses at my disposal. I can say that this was an incapacity linked undoubtedly with the political situation in which we found ourselves. It is hard to see where, either on the Right or the Left, this problem of power could then have been posed. On the Right, it was posed only in terms of constitution, sovereignty, and so on, that is, in juridical terms; on the Marxist side, it was posed only in terms of the state apparatus. The way power was exercised - concretely, and in detail - with its specificity, its techniques and tactics, was something no one attempted to ascertain; they contented themselves with denouncing it in a polemical and global fashion as it existed among the "other," in the adversary camp. Where Soviet socialist power was in question, its opponents called it totalitarianism; power in Western capitalism was denounced by the Marxists as class domination; but the mechanics of power in themselves were never analyzed.

I was lonely, deadly lonely. And I was to find out then, as I found out so many times, over and over again, that women especially are social beings, who are not content with just husband and family, but must have a community, a group, an exchange with others. Young and old, even in the busiest years of our lives, we women especially are victims of the long loneliness.It was years before I woke up without that longing for a face pressed against my breast, an arm about my shoulder. The sense of loss was there.I never was so unhappy, never felt so great the sense of loneliness. No matter how many times I gave up mother, father, husband, brother, daughter, for His sake, I had to do it over again.Tamar is partly responsible for the title of this book in that when I was beginning it she was writing me about how alone a mother of young children always is. I had also just heard from an old woman who lived a long and full life, and she too spoke of her loneliness

In 1953, Allen Dulles, then director of the USA Central Intelligence Agency (CIA), named Dr Sidney Gottlieb to direct the CIA's MKULTRA programme, which included experiments conducted by psychiatrists to create amnesia, new dissociated identities, new memories, and responses to hypnotic access codes. In 1972, then-CIA director Richard Helms and Gottlieb ordered the destruction of all MKULTRA records. A clerical error spared seven boxes, containing 1738 documents, over 17,000 pages. This archive was declassified through a Freedom of Information Act Request in 1977, though the names of most people, universities, and hospitals are redacted. The CIA assigned each document a number preceded by "MORI", for "Managament of Officially Released Information", the CIA's automated electronic system at the time of document release. These documents, to be referenced throughout this chapter, are accessible on the Internet (see: abuse-of-power (dot) org/modules/content/index.php?id=31). The United States Senate held a hearing exposing the abuses of MKULTRA, entitled "Project MKULTRA, the CIA's program of research into behavioral modification" (1977).

This heart within me I can feel, and I judge that it exists. This world I can touch, and I likewise judge that it exists. There ends all my knowledge, and the rest is construction. For if I try to seize this self of which I feel sure, if I try to define and to summarize it, it is nothing but water slipping through my fingers. I can sketch one by one all the aspects it is able to assume, all those likewise that have been attributed to it, this up bringing, this origin, this ardor or these silences, this nobility or this vileness. But aspects cannot be added up. This very heart which is mine will forever remain indefinable to me. Between the certainty I have of my existence and the content I try to give to that assurance, the gap will never be filled. Forever I shall be a stranger to myself. In psychology as in logic, there are truths but no truth. Socrates' "Know thyself" has as much value as the "Be virtuous" of our confessionals. They reveal a nostalgia at the same time as an ignorance. They are sterile exercises on great subjects. They are legitimate only in precisely so far as they are approximate.

This heart within me I can feel, and I judge that itexists. This world I can touch, and I likewise judge that it exists. There ends all my knowledge, and the rest isconstruction. For if I try to seize this self of which I feel sure, if I try to define and to summarize it, it is nothingbut water slipping through my fingers. I can sketch one by one all the aspects it is able to assume, all thoselikewise that have been attributed to it, this up bringing, this origin, this ardor or these silences, this nobility orthis vileness. But aspects cannot be added up. This very heart which is mine will forever remain indefinable tome. Between the certainty I have of my existence and the content I try to give to that assurance, the gap willnever be filled. Forever I shall be a stranger to myself. In psychology as in logic, there are truths but no truth.Socrates' "Know thyself" has as much value as the "Be virtuous" of our confessionals. They reveal a nostalgia atthe same time as an ignorance. They are sterile exercises on great subjects. They are legitimate only in preciselyso far as they are approximate.

This heart within me I can feel, and I judge that it exists. This world I can touch, and I likewise judge that it exists. There ends all my knowledge, and the rest is construction. For if I try to seize this self of which I feel sure, if I try to define and to summarize it, it is nothing but water slipping through my fingers. I can sketch one by one all the aspects it is able to assume, all thoselikewise that have been attributed to it, this up bringing, this origin, this ardor or these silences, this nobility or this vileness. But aspects cannot be added up. This very heart which is mine will forever remain indefinable to me. Between the certainty I have of my existence and the content I try to give to that assurance, the gap will never be filled. Forever I shall be a stranger to myself. In psychology as in logic, there are truths but no truth. Socrates' "Know thyself" has as much value as the "Be virtuous" of our confessionals. They reveal a nostalgia at the same time as an ignorance. They are sterile exercises on great subjects. They are legitimate only in precisely so far as they are approximate.

But this house felt strange. Dave asked what was going on, and John explained that the name on the eviction order belonged to the mother of several of the children. She had died two months earlier, and the children had simply gone on living in the house, by themselves. As the movers swept through the rooms, Gray Eyes took charge, giving orders to the other children; the youngest was a boy of about eight or nine. Upstairs, the movers found ratty mattresses on the floor and empty liquor bottles displayed like trophies. In the damp basement, clothes were flung everywhere. The house and the yard were littered with trash. “Disgusting,” Tim said to the roaches scaling the kitchen wall. As the landlord changed the locks with a power drill and the movers pushed the contents of the house onto the wet curb, the children began to run around and laugh. When the move was done, the crew gathered by the trucks, instinctively stomping the ground to shake loose any stowaway roaches. Those who smoked reached for their packs. They didn’t know where the children would go, and they didn’t ask.

In the presence of Esch, values have hidden their faces. Order, loyalty, sacrifice—he cherishes all these words, but exactly what do they represent? Sacrifice for what? Demand what sort of order? He doesn't know.If a value has lost its concrete content, what is left of it? A mere empty form; an imperative that goes unheeded and, all the more furious, demands to be heard and obeyed. The less Esch knows what he wants, the more furiously he wants it. Esch: the fanaticism of the era with no God. Because all values have hidden their faces, anything can be considered a value. Justice, order—Esch seeks them now in the trade union struggle, then in religion; today in police power, tomorrow in the mirage of America, where he dreams of emigrating. He could be a terrorist or a repentant terrorist turning in his comrades, or a party militant or a cult member a kamikaze prepared to sacrifice his life. All the passions rampaging through the bloody history of our time are taken up, unmasked, and terrifyingly displayed in Esch's modest adventure.

Our contemporaries are constantly excited by two conflicting passions; they want to be led, and they wish to remain free: as they cannot destroy either one or the other of these contrary propensities, they strive to satisfy them both at once. They devise a sole, tutelary, and all-powerful form of government, but elected by the people. They combine the principle of centralization and that of popular sovereignty; this gives them a respite: they console themselves for being in tutelage by the reflection that they have chosen their own guardians. Every man allows himself to be put in leading-strings, because he sees that it is not a person or a class of persons, but the people at large that holds the end of his chain.By this system the people shake off their state of dependence just long enough to select their master, and then relapse into it again. A great many persons at the present day are quite contented with this sort of compromise between administrative despotism and the sovereignty of the people; and they think they have done enough for the protection of individual freedom when they have surrendered it to the power of the nation at large. This does not satisfy me: the nature of him I am to obey signifies less to me than the fact of extorted obedience.