People ask what my influences are, and for me, it's not always obvious. One of my biggest inspirations was Chrissie Hynde from the Pretenders. That's based on how she just does whatever she wants to do, and I love her attitude about everything. It bleeds over into my way of thinking and comedy.
I design all of my costumes. I like to go out there and feel like I have contributed to every part of what I do. I choose the music, the choreographer, I've obviously chosen my coach, my costumes - all if that falls under my realm of power, my realm of influence.
“Psychoanalysis is often about turning our ghosts into ancestors, even for patients who have not lost loved ones to death. We are often haunted by important relationships from the past that influence us unconsciously in the present. As we work them through, they go from haunting us to becoming simply part of our history.”
The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity of influenza HA. They probed in more detail the precise codons that are used by the virus to encode the influenza HA1 protein. The discriminated between codons on the basis of volatility. Each three-nucleotide codon is related by a single nucleotide change to nine 'mutational neighbours.' Of those nine mutations, some proportion change the codon to a synonymous codon and some change it to a nonsynonymous one, which directs the incorporation of a different amino acid into the protein. More volatile codons are those for which a larger proportion of those nine mutational neighbours encode an amino acid change. The use of particular codons in a gene at a frequency that is disproportionate to their random selection for encoding a chosen amino acid is termed codon bias. Such bias is common and is influenced by many factors, but here the collaborators found strong evidence for codon bias that was particular for and restricted to the amino acids making up the HA1 epitopes. Remarkably, they observed that influenza employs a disproportionate number of volatile codons in its epitope-coding sequences. There was a bias for the use of codons that had the fewest synonymous mutational neighbours. In other words, influenza HA1 appears to have optimized the speed with which it can change amino acids in its epitopes. Amino acid changes can arise from fewer mutational events. The antibody combining regions are optimized to use codons that have a greater likelihood to undergo nonsynonymous single nucleotide substitutions : they are optimized for rapid evolution.
“For the ordinary man is passive. Within a narrow circle (home life, and perhaps the trade unions or local politics) he feels himself master of his fate, but against major events he is as helpless as against the elements. So far from endeavoring to influence the future, he simply lies down and lets things happen to him.”
“Minimalism isn't just one kind of music. Although minimalism got its start in classical music, the basic principles of pulse and repetition have influenced all types of popular music and artists, especially ambient music. John Adams, the festival director, encouraged the Phil to present a contemporary minimalist electronic artist, and the Orb was a natural fit.”
“The Anglo-Saxon has established himself in climates totally diverse - Canada, South Africa, and India - and, through several generations, has preserved his essential race characteristics. He is not, of course, superior to climatic influences; but even in warm climates, he is likely to retain his aggressive vigor long enough to supplant races already enfeebled.”
“Consciousness will always be present, though a particular consciousness may cease. For example, the particular tactile consciousness that is present within this human body will cease when the body comes to an end. Likewise, consciousnesses that are influenced by ignorance, by anger or by attachment, these too will cease. But the basic, ultimate, innermost subtle consciousness will always remain. It has no beginning, and it will have not end.”
“I never saw Ken Lay as a huge energy player. I think a lot of people did. I saw him as a trading company. That's why I never really allowed him to exert any type of influence over me on what power companies or what utility companies should be doing in this energy industry.”
“I think it's an honor to be a role model to one person or maybe more than that. If you are given a chance to be a role model, I think you should always take it because you can influence a person's life in a positive light, and that's what I want to do. That's what it's all about.”